Vitoli and Gerosuppressive Agents

By Eric Simard, doctor of biology and researcher (www.esimard.com).

Did you know that cutting-edge research on cellular longevity, carried out here in Quebec, has achieved the best results published so far in a high-level scientific journal? This research is even at the origin of a product line of high-quality natural products, produced here in Quebec: Vitoli® products. Let's dive into the history of this growing Quebec company as recently highlighted by La Presse +.

The secret of longevity

An ambitious research program, carried out with the support of the Natural Science and Engineering Research Council of Canada (NSERC) for more than 7 years, aims to increase cellular longevity. This research aims to identify natural molecules capable of modulating the metabolic pathways of primary aging. Recent discoveries have shown that it is possible to act on aging in order to maintain our capacities for longer. Vitoli® Healthy Aging was developed specifically for this reason. We will come back to this later.

Note that aging is not just the result of wear and tear caused by oxidation. It took more than 10 years for a new theory to be defended by sientists in the field in 2013, proving that a researcher who put forward this hypothesis in 1957 was right (George C. Williams, 1926 - 2010: antagonistic pleiotropy ( 1957)). It was later renamed (Mikhail V. Blagosklonny): the hyperfunction theory.

Here is an elaboration to help you better understand the scope of this research.

Gerosuppressive agents

From the moment these cellular mechanisms were linked to aging, in the mid-2000s, it was possible to search for molecules that could influence these processes. Certain natural molecules have effects of modulating the mechanisms involved in the higher longevity of certain living beings. Those of which, are very few. The molecules capable of slowing down primary aging were initially called “calorie restriction mimetics”.

We now call these molecules gerosuppressive agents; from the Greek root "gero" which means aging and "suppressor" for slowing down the process. This term better represents the objective pursued. The mimicry of calorie restriction was not intended to reduce calorie intake, but to replicate the benefits by slowing down primary aging.

Olive polyphenols

In 2013, a Spanish research group used the term 'gerosuppressants' to categorize the multiple health benefits of olive polyphenols by linking them to aging processes. A second article, from another independent research group, confirmed this claim in 2019 with a comprehensive literature review. By reviewing 194 scientific references, de Pablos' team and collaborators (2019) summarized both cellular mechanisms, animal models, and clinical studies performed. These beneficial effects of olive polyphenols are at the origin of a large part of health benefits of this oil, which is so important for the Mediterranean diet.

It is possible to extract these precious molecules directly from the olives to guarantee the quantity ingested. With the help of state-of-the-art extraction technology, Idunn Technologies uses a proprietary extract of olive polyphenols to add these benefits to each Vitoli product. The dose used corresponds to the dose consumed daily by followers of the Mediterranean diet in Europe. It is important to remember that Idunn Technologies, the company I created that markets Vitoli® products, initiated the research program with Concordia University.

More efficient Quebec products

A wide analysis of the scientific literature had led the European Union to approve a health claim for 5 mg of certain olive polyphenols. This is a claim for reducing the risk of cardiovascular disease related to the blockage of the arteries by oxidized bad cholesterol (known as atherosclerosis). It is on this health claim that we based the dosage of the Provitol® Complex in Vitoli® products.

Thus, in each Vitoli® product (there are 12 different products in total), you benefit from the presence of olive polyphenols, at the dose recommended by the European Union, to which are added the plant extracts with the most scientific demonstrations for each of the targeted applications. Our in-depth knowledge of the field of longevity in health has led us to supplement certain formulas with vitamins and minerals when this contribution was considered significant. For example, Vitoli® Immunity, in addition to containing plant extracts with the best non-specific antiviral effects, also contains zinc and vitamin D3 necessary for better health of the immune system.

As mentioned at the beginning of the article, Vitoli® Healthy Aging has been specifically developed to act on aging. We have added resveratrol to the exclusive olive polyphenols of the Provitol Complex to reflect an important discovery made with Concordia University. Resveratrol is a modulator of the proteins responsible for cellular repair: sirtuins. A recent scientific article reports 244 clinical studies published on this molecule and 27 others still in progress when it was published in 2019.

Thus, Vitoli Healthy Aging is a product marketed to help you maintain your abilities as long as possible. It is authorized for sale by Health Canada with the number NPN800633775 and the claim "Provides antioxidants".

References

-Costantiniet al, 2017. The Greenland shark: A new challenge for the oxidative stress theory of ageing? CompBiochemPhysiol A Mol IntegrPhysiol. 2017 Jan;203:227-232.

-de Pablos et al, 2019. Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immunemediated and neurodegenerative diseases. PharmacologicalResearch 143 (2019) 58–72.

-Eric Simard, Dr en biologie. 2016. Vivre jeune plus longtemps ; Chapitre 3.2, Les polyphénols d’olives et la diète méditerranéenne. Marcel Broquet la Nouvelle édition. 364 pages.

-Galiniak S, Aebisher D, Bartusik-Aebisher D. Health benefits of resveratrol administration. Acta Biochim Pol. 2019 Feb28;66(1):13-21. doi: 10.18388/abp.2018_2749. PMID: 30816367.

-Kaeberlein, 2015. Healthy aging: The ultimate preventative medicine. Science, 2015 Dec 4 ;350(6265) :1191-3.

-Menendez et al, 2013. Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil. A new family of gerosuppressant agents. Cell Cycle 12:4, 555–578; February 15, 2013.

-Mikhail V. Blagosklonny, 2013. Big mice die young but large animals live longer. AGING, Avril 2013, Vol. 5 No 4.

-Newgard, C.B., Pessin, J.E. 2014. Recent progress in metabolic signaling pathways regulating aging and life span. J Gerontol A Biol Sci Med Sci. Jun;69 Suppl 1:S21-7. Review.

-Peyrolet al, 2017. Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders. Review. Nutrients 2017, 9, 306.

-Singh AP, Singh R, Verma SS, Rai V, Kaschula CH, Maiti P, Gupta SC. Health benefits of resveratrol: Evidence from clinical studies. Med Res Rev. 2019 Sep;39(5):1851-1891. doi: 10.1002/med.21565. Epub 2019 Feb 11. PMID: 30741437.